Introduction:
We investigated the outcomes of pT0 after robot-assisted radical cystectomy (RARC).
Methods:
A retrospective review of the International Robotic Cystectomy Consortium database was performed. Patients with pT0 after RARC were identified and analyzed. Data were reviewed for demographics, and pathologic outcomes. Kaplan Meier (KM) curves were used to depict recurrence free survival (RFS), disease specific survival (DSS), and overall survival (OS). Multivariate stepwise Cox regression models were used to identify variables associated with RFS and OS.
Results:
471 patients were identified. Median age was 68 (IQR 60-73), with a median follow up of 20 months (IQR 6-47), 37% received NAC, and 5% had pN positive disease. Eight percent of patients experienced disease recurrence: 3% and 5% local and distant recurrence, respectively. The most common sites of local and distant recurrences were the pelvis (1%) and lungs (2%), respectively. No patient had port-site or peritoneal recurrence. Five-year RFS, DSS, and OS were 88%, 93% and 79%, respectively (Fig. 1). Predictors of RFS were age (p=0.02), pN+ve (p<0.01), and reoperations within 30 days (p<0.01). Predictors of OS were chronic kidney disease (p<0.01), neoadjuvant chemotherapy (p=0.03), pN+ve (p<0.01), and reoperations within 30 days (p=0.03) (Table 1). Predictors for DSS could not be calculated due to small number of patients <10.
Conclusion:
Despite pathologic T0 status at RARC, positive nodal disease occurred in 5%, and 8% of patients relapsed. Node status is the main predictor for recurrence in pT0.
Funding: Roswell Park Alliance Foundation and The Vattikuti Foundation Collective Quality Initiative
Image(s) (click to enlarge):
RELAPSES RATES AND PATTERNS FOR PATHOLOGICAL T0 AFTER ROBOT-ASSISTED RADICAL CYSTECTOMY: RESULTS FROM THE INTERNATIONAL ROBOTIC CYSTECTOMY CONSORTIUM
Category
Bladder Cancer > Non-Muscle Invasive Bladder Cancer
Description
Poster #6
Wednesday, Dec 1
1:00 p.m. - 2:00 p.m.
Bladder 1
Presented By: Yousuf Ramahi
Authors:
Ahmed S. Elsayed
Umar Iqbal
Zhe Jing
Carl Wijburg
Andrew A. Wagner
Abolfazl Hosseini
Peter Wiklund
Michael Stöckle
Eric Kim
Prokar Dasgupta
Mohammed S. Khan
John Kelly
Jihad Kaouk
Ketan Badani
Juan P. Redorta
Alexander Mottrie
Morgan Roupert
Derya Balbay
Lee Richstone
Koon Ho Rha
Ahmed Aboumohamed